Intestinal amyloidosis: Clinical manifestations and diagnostic challenge
نویسندگان
چکیده
Amyloidosis is a heterogeneous group of diseases in which the extracellular deposition abnormal fibrillar proteins disrupts tissue structure and function. Intestinal involvement very rare manifestation amyloidosis compared to most affected organs, heart kidneys. Damage gastrointestinal tract may be only amyloidosis, or - more often component several organs systemic amyloidosis. Any part digestive can involved; however, small bowel part, followed by colon. characterized clinical picture, with weight loss, chronic diarrhea, abdominal pain, intestinal bleeding, pseudo-obstruction. Endoscopic findings are fine granular appearance, erosions, ulcerations, mucosal friability, multiple protrusions, tumor-like lesions. Pathologic examination allows for definitive diagnosis using Congo red staining positive sample apple-green birefringence. The disease easily misdiagnosed other lead diagnostic challenges practice. Further, amyloid colonic mimic inflammatory disease, malignancy, ischemic colitis, collagenous colitis. Therefore, gastroenterologists need include their work-up.
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ژورنال
عنوان ژورنال: Advances in Clinical and Experimental Medicine
سال: 2021
ISSN: ['2451-2680', '1899-5276']
DOI: https://doi.org/10.17219/acem/133521